Endocrine Abstracts

Type 1 diabetes mellitus is usually believed to present acutely and it is assumed that metabolic decompensation is sudden.We present 3 cases of asymptomatic type 1 diabetesCase1A 28 year old asymptomatic gentleman moved to a new surgery and glycosuria was noted as part of routine screening , no ketonuria., body mass index 21, no past medical illness or any family history of diabetes. His fasting blood glucose...

Hyponatraemia is recognised as a serious metabolic emergency with varied aetiology. We report an unusual case of hyponatraemia.A 36 year old woman was admitted following a seizure. Her relationship with her boyfriend had recently ended. She was disorientated with a GCS of 11/15. She was apyrexial and examination was unremarkable. Old notes recorded an interest in complimentary health and 'systemic' candidiasis.A drug overdose was suspected until plasma biochemistry ret...

A 54yr old female presented with a 12-month history of tremor, sweating, anxiety and occasional palpitations. There was no past medical or family history of note. On examination, she had a fine tremor but no neck masses or eye signs. Her FT4 20.8 pmol/l (8pmol/l-22pmol/l), FT3 7.3 pmol/l (3.5-6.5pmol/l) with a suppressed TSH less than 0.01mu/l (0.35mu/l-5.5mu/l); 99Tc scan showed an autonomous hot nodule in the right lower lobe of the thyroid with partial suppression of the re...

Primary hyperaldosteronism ('Conn's syndrome') may have a prevalence as high as 10% in hypertensive patients, and in some cases there may not be obvious hypokalaemia. Recently the use of a single aldosterone/ renin ('A/R') ratio has been advocated as a screening test for Conn's, and less influence by anti-hypertensive drug therapy has been claimed.We have established a cut-off for ambulant A/R ratios of 25 ng/mU using the DPC'Coat-a-Count' aldosterone method and the Nichols 'A...